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Predominantly, these drugs are given by mouth, but they can also be administered rectally as suppositories(e.g.diclofenac, indomethacin, ketoprofen, meloxicam, naproxen) topically as cream/gel (e.g. diclofenac: Emulgel;) intravenous (diclofenac)intramuscular (e.g.diclofenac/piroxicam/ketoprofen)

In general, the maximum dose for NSAIDs should be set at 1.5-2 times the standard recommended starting dose. Failure with one drug does not preclude trial of a different one (provided the failure relates to efficacy rather than adverse effects).

However, trials must be sequential.

If taking NSAIDs orally, it is best to take them with or after food, to help minimise any adverse effects on the stomach.