Hi Mitsuyo,
I'll try to answer your queries:
1. Can the scarring \"spread\" in the case of chemically induced AA (myelogram, ESI, etc) as opposed to mechanically induced AA (surgery, etc)?
2. What are the definitions of diffuse damage and focal (localized) damage?
3. What are the differences between them?
4. Is it that the chemicals travel in the spine? Can they go upward as well as downward?
5. I guess scarring occurs because of an insult. So, if the insult is local, then is the scarring also local? If the insult is spread, can the scarring also spread (or seems like it's spreading)?
6. Diffuse or focal, chemically induced or mechanically induced: How do their symptoms differ from each other? Are locations and/or severity of symptoms different in general?
7. How can we assess or \"measure\" the progress of AA? I think our pain level and symptoms can be influenced by many different factors, such as the level of activity as well as inactivity, one's medical history, aging, stress, etc. In some cases, it might be a clear-cut thing. But how do we know which cases are such cases?
1. see my previous answer, but in brief, yes.
2. Focal = in a small area, e.g. at one spinal level such as L5 for example; may affect one nerve root specifically; diffuse= over a wider area, often several levels
3. I hope 2 is self-explanatory
4. Yes to both questions
5. Yes
6. Focal is more likely to cause circumscribed symptoms relating to the affected nerve root. Neuropathic pain, sometimes weakness etc. Diffuse is more likely to cause symptoms relating to several nerve roots plus often other symptoms such as bladder/bowel dysfunction. Symptoms will depend on how severe the scarring is and how many nerve roots are affected. If severe, arach. can cause CSF flow to be impeded and this can have knock-on effects at higher (or lower) levels because the spinal canal is a closed system so it is a bit like standing on a hosepipe, the pressure will back up. Don't forget, some symptoms will be secondary musculoskeletal and others will relate to any original underlying problems. Chemically induced arach. can cause a wide variety of symptoms (a syndrome) : see the survey results.
7. It can be difficult to measure progression of symptoms, not least because it is common for them to fluctuate, in a pattern of flare-up and remission cycles.As you rightly say, there are many different factors which will affect individuals.
Hope this helps!!
Regards,
DocSarah